Same issue here with a Thinkpad Helix and USB 3.0 docking running with 2x 24" monitors at 1920x1200 via DVI. OS is Win8 64-bit.
The lag occurs especially when switching from an application displayed on one monitor to another application displayed on the other monitor.
There's also a bit of lag when switching between cells in Excel or switching between applications. For instance: if alt-tabbing from Excel to Outlook, the mouse will "hang" for a sec after alt-tabbing. This is very consistent.
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