Config:
Lenovo Carbon X1 (non-touch)
Windows 7 Home Premium 64
Lenovo USB 3.0 Hub
Logitech AnyNet wireless mouse and keyboard
2x external Samsung 24" 1900x1200 monitors via hub via DVI
1x external Hanns-G 17" 1400x900 monitor via mini HDMI-VGA converter directly from laptop
I've been struggling with mouse and keyboard lag across all three external screens, regardless of whether I use the wireless mouse or the laptop's built-in touchpad and keyboard. I'm running the latest Lenovo drivers for the laptop, the latest BIOS update, the latest USB Hub software and firmware.
The issue of mouse and keyboard lag seemed to be affecting everything I did on my laptop so long as I was plugged into the USB 3.0 hub from Lenovo. Turning off monitors reduced the lag but didn't eliminate it. I've applied the suggested power settings, I've moved my wireless mouse to an extender and kept the receiver far from the USB 3.0 cables and ports. I've also plugged the mouse into the secondary USB 2.0 port on the left side of my chassis, far from the USB 3.0 cable.
On a hunch, I went into the BIOS and changed my USB 3.0 speed settings from "Automatic" to "Enabled." With ALL other fixes suggested in this post now applied, I now have a fairly successful setup with 4 monitors. I can run video on one monitor, a web browser in another, and an excel document in yet another. This is excellent.
However, I notice that SOME web sites cause a little bit of lag. I'm not sure this has ANYTHING to do with DisplayLink or my multiple monitor setup. Sites that have busy scripting like Facebook or NBCNews seem to be the easiest sites to replicate the problem. However, simple sites like Google or Reddit don't cause any lag.
So, without further adieu, I'll confirm this problem resolved for me. Please let me know if you have any questions about my configuration if you'd like to attempt to emulate my blissful world of mediocrity.