The external display only issue is likely to be the OS one we have been dealing with under the thread called with lag in the title. The fact you only see the issue in replace mode seems to confirm it is the same problem.
We are waiting for the OS fix to be back-ported to Windows 10 v1607. It has been rolled out on Windows Insiders Program who use the next version of Windows 10.
For DisplayLink driver, there is no difference if we are the only monitor, or if there are 1+ panels connected to the graphics card.
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