Also experiencing this issue
Netflix was the thing that helped me realize that it's the Chrome browser that's the issue (Netflix stuttering etc). Netflix doesn't even have to be on the USB connected monitor to have the issue - so long as the monitors (I use two USB monitors) are connected, the issue is there.
As well, I can see evidence of the issue without Netflix running - general poor/stutter behavior from other apps - primarily browser driven apps (they may be based on Chromium?)
Windows 10x64 1607
Xeon E5-1660 3.3GHz
32GB ram
1x nVidia Quadro 600
2x nVidia GeForce GT 610
2x Startech DisplayPort to USB adapters
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