I'm encountering the same issue as well with my new M4 MacBook Pro. I'm using two Plugable UGA-4KDP adapters to connect my MacBook Pro to external monitors. Worked fine on my old Intel Mac, but just switched to a new M4 and am having issues.
My issues are mainly with Chrome and Slack: the display is super-laggy when scrolling and dragging and dropping, and the pointer sometimes skips around. Don't have issues with the primary display with the same pointer, so it's not a mouse issue. For some reason, I don't have a similar issue in Apple Mail.
I'll go ahead and send my details to that same email address listed above.
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