Thanks stfm, the profile you posted is a nice improvement already. Even with it, though, light grays still don't come out too well, like the mouseover background colour for result items here, pretty much invisible:
https://duckduckgo.com/?q=mb169b%2B+ this is not only a problem for colour critical work, but also for subtle color hints when editing text or code. Would it make sense to have multiple profiles, each optimized for a different kind of task (say text editing vs. working with photos)?