I'm running 10.10 and echo the comments above. It's usable with the 2.2 driver, but I get request slow downs in performance, artefacts on the display and problems with the dock/transparency/etc.
I'm running 2 additional displays - one on Thunderbolt and another from USB.
Don't have any issues with orientation or power. I was happy with 2.2 on Mavericks and I think that Yosemite is close-isn to where it needs to be for my needs.
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