We have run tests with a number of USB-C adapters and USB products with a 2016 MacBook without encountering particular USB issues.
We're going to test the 2015 MacBook next: the USB host controller is different.
We've observed the same issue Paul found: in systems with recent Intel GPUs sometimes the internal screen does not resume from sleep when USB screens are connected.
The same happens sometimes on warm reboots and we've seen a similar behaviour logging out and in again.
This is a Sierra issue not depending on USB-C but since all MacBooks have a single recent Intel GPU, they are all potentially affected.
If you see this issue please open a bug with Apple: this is the last severe issue not yet fixed in the latest Sierra beta!
Best regards,
Carlo
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